Randall Kimple, MD, PhD
Co-leader, Project 4
Collaborator, Project 1
Collaborator, Pathology Core
Dr. Kimple is an assistant professor in the Department of Human Oncology and a member of the UW Carbone Cancer Center and the UW Institute for Clinical and Translational Research. His research focuses on ways to improve treatment outcomes for patients with head and neck cancers. Specifically, his lab seeks to uncover molecular mechanisms leading to increased sensitivity to therapy in HPV-positive cancers and how to target therapeutic resistance in head and neck cancer.
Dr. Kimple’s lab utilizes cellular and mouse models that they developed, including patient-derived xenografts (PDX) and intrinsic resistance models to understand therapeutic response. He led the development and characterization of the head and neck PDX model system at the University of Wisconsin, has active collaborations with Dr. Deric Wheeler related to the role of AXL in cetuximab and radiation resistance and has ongoing research projects investigating the role of cancer initiating cells in therapeutic resistance.
His clinical practice is focused on the treatment of patients with malignancies of the head and neck as a member of the UW Multidisciplinary Head and Neck Program. This program interacts regularly with head and neck surgeons, medical oncologists, radiologists, speech swallow therapists and numerous other specialists depending upon the individual case. Dr. Kimple is active in the NRG Oncology Group, serves as principal investigator on several active clinical trials and institutional review board approved protocols and actively enrolls patients in both national and investigator initiated trials open at UW.
Education
Postdoctoral Fellow, University of Wisconsin, Tumor Virology (2012)
Postdoctoral Fellow, University of North Carolina at Chapel Hill, Cancer Biology (2010)
Residency, University of North Carolina at Chapel Hill, Radiation Oncology (2010)
Intern, University of North Carolina at Chapel Hill, Internal Medicine (2006)
MD, University of North Carolina at Chapel Hill, Medicine (2005)
PhD, University of North Carolina at Chapel Hill, Pharmacology (2003)
BS, Michigan State University, Environmental Science and Management (1998)
Academic Appointments
Assistant Professor, Human Oncology, Medical Physics (2012)
Visiting Assistant Professor, Human Oncology (2010)
, Human Oncology
Selected Honors and Awards
2011 Canadian Association Radiation Oncology (CARO) Lecturer
2010 The Chaney Award for Excellence in Physics Research, University of North Carolina
2010 Kaye Postdoctoral Fellow in Head and Neck Cancer Research, University of Wisconsin
2009 Roentgen Resident Research Award , University of North Carolina
2009 Chief Resident, University of North Carolina Hospitals
2008 Vail Workshop: Methods in Clinical Cancer Research, AACR/ASCO
Boards, Advisory Committees and Professional Organizations
2001-pres. Member, American Society for Pharmacology and Experimental Therapeutics
2006-pres. Member, American Society for Radiation Oncology
2006-pres. Member, Radiological Society of North America
2006-pres. Member, American Society of Clinical Oncology
2008-pres. Member, American Association for Cancer Research
2010-pres. Member, University of Wisconsin Institute for Clinical and Translational Research
2012-pres. Member, University of Wisconsin Carbone Cancer Center
2014-pres. Senior Associate Editor, International Journal of Radiation Oncology Biology and Physics
Contact Information
Randall Kimple, MD, PhD
1111 Highland Avenue, 3107 WIMR,Madison, WI 53705