Randall Kimple, MD, PhD

Randall Kimple, MD, PhD

Co-leader, Project 4

Collaborator, Project 1

Collaborator, Pathology Core

Dr. Kimple is an assistant professor in the Department of Human Oncology and a member of the UW Carbone Cancer Center and the UW Institute for Clinical and Translational Research. His research focuses on ways to improve treatment outcomes for patients with head and neck cancers. Specifically, his lab seeks to uncover molecular mechanisms leading to increased sensitivity to therapy in HPV-positive cancers and how to target therapeutic resistance in head and neck cancer.

Dr. Kimple’s lab utilizes cellular and mouse models that they developed, including patient-derived xenografts (PDX) and intrinsic resistance models to understand therapeutic response. He led the development and characterization of the head and neck PDX model system at the University of Wisconsin, has active collaborations with Dr. Deric Wheeler related to the role of AXL in cetuximab and radiation resistance and has ongoing research projects investigating the role of cancer initiating cells in therapeutic resistance.

His clinical practice is focused on the treatment of patients with malignancies of the head and neck as a member of the UW Multidisciplinary Head and Neck Program. This program interacts regularly with head and neck surgeons, medical oncologists, radiologists, speech swallow therapists and numerous other specialists depending upon the individual case. Dr. Kimple is active in the NRG Oncology Group, serves as principal investigator on several active clinical trials and institutional review board approved protocols and actively enrolls patients in both national and investigator initiated trials open at UW.


Postdoctoral Fellow, University of Wisconsin, Tumor Virology (2012)

Postdoctoral Fellow, University of North Carolina at Chapel Hill, Cancer Biology (2010)

Residency, University of North Carolina at Chapel Hill, Radiation Oncology (2010)

Intern, University of North Carolina at Chapel Hill, Internal Medicine (2006)

MD, University of North Carolina at Chapel Hill, Medicine (2005)

PhD, University of North Carolina at Chapel Hill, Pharmacology (2003)

BS, Michigan State University, Environmental Science and Management (1998)

Academic Appointments

Assistant Professor, Human Oncology, Medical Physics (2012)

Visiting Assistant Professor, Human Oncology (2010)

, Human Oncology

Selected Honors and Awards

2011 Canadian Association Radiation Oncology (CARO) Lecturer

2010 The Chaney Award for Excellence in Physics Research, University of North Carolina

2010 Kaye Postdoctoral Fellow in Head and Neck Cancer Research, University of Wisconsin

2009 Roentgen Resident Research Award , University of North Carolina

2009 Chief Resident, University of North Carolina Hospitals

2008 Vail Workshop: Methods in Clinical Cancer Research, AACR/ASCO

Boards, Advisory Committees and Professional Organizations

2001-pres. Member, American Society for Pharmacology and Experimental Therapeutics

2006-pres. Member, American Society for Radiation Oncology

2006-pres. Member, Radiological Society of North America

2006-pres. Member, American Society of Clinical Oncology

2008-pres. Member, American Association for Cancer Research

2010-pres. Member, University of Wisconsin Institute for Clinical and Translational Research

2012-pres. Member, University of Wisconsin Carbone Cancer Center

2014-pres. Senior Associate Editor, International Journal of Radiation Oncology Biology and Physics

Contact Information

Randall Kimple, MD, PhD

1111 Highland Avenue, 3107 WIMR,
Madison, WI 53705