Wisconsin Head and Neck Cancer SPORE
A collaborative cancer research project

Pathology and Biospecimen Core

Rong Hu, MD, PhD

Director: Rong Hu, MD, PhD

Associate Professor
Pathology and Laboratory Medicine
University of Wisconsin

David Yang, MD

Co-director: David Yang, MD

Professor
Pathology and Laboratory Medicine
University of Wisconsin

Summary:

The Path Core is a centralized service that is responsible for the standardized acquisition, storage, characterization and distribution of human tissues to HNC investigators. The success of any clinical trial hinges on investigators producing accurate and reliable preclinical data. The Path Core’s mission for biospecimen quality and efficiency is critical in helping investigators achieve these results.

 

Specific Aims:

  • Aim 1: To collect, process, preserve and distribute HNC biospecimens.

  • Aim 2: To provide and maintain a centralized HN SPORE biospecimen bioinformatics database.

  • Aim 3: To provide a full range of expert services for biospecimen characterization.

  • Aim 4: To serve and support HN SPORE investigators and collaborate with other investigators in the HNC research community.

Examples of Path Core Resources:

Summary of WI HN SPORE Tissue MicroArrays

# of cases Matched primary/LN Mets Matched benign # of cores Size of cores (mm)
HNC TMA 92 42 N/A 525 0.6
ACC 55 1 55 339 0.6
OCSCC #1 44 44 N/A 264 1
OCSCC #2 45 45 N/A 270 1
HPSCC 52 37 N/A 276 1
OPSCC #1 68 68 N/A 432 0.6
OPSCC #2 103 10 N/A 417 0.6
OPSCC #3 103 57 N/A 525 0.6
Larynx #1 52 34 N/A 266 1
Larynx #2 72 18 N/A 272 1
Sinonasal 75 2 4 (papilloma) 261 1
ICI treated HNC 23 4 N/A 84 2

Cases are included in triplicate.

Abbreviations

OCSCC  oral cavity squamous cell carcinoma
OPSCC  oropharyngeal squamous cell carcinoma
HPSCC  hypopharynx squamous cell carcinoma
ACC  adenoid cystic carcinoma

 

 

 

Collaborators:

Paul Lambert, PhDPaul Lambert, PhD

Director, McArdle Laboratory for Cancer Research
Professor and Chair of Oncology
University of Wisconsin

 

Darya Buehler, MDDarya Buehler, MD

Pathologist
Associate Professor of Pathology & Laboratory Medicine
University of Wisconsin

 

Tiffany Glazer, MDTiffany Glazer, MD

Head and Neck Surgeon
Assistant Professor of Surgery-Otolaryngology
University of Wisconsin

 

Randall Kimple, MD, PhDRandall Kimple, MD, PhD

Radiation Oncologist
Associate Professor of Human Oncology
University of Wisconsin

 

 

Karla Esbona, PhDKarla Esbona, PhD

Scientific Manager, TRIP Lab
Department of Pathology & Laboratory Medicine
University of Wisconsin

Request HN SPORE Pathology Resources

  • HNC Cell Lines
  • HNC Patient Derived Xenografts
  • HNC Tissue Microarrays
  • HNC histology services
  • HNC Biospecimens

Acknowledge Pathology Core for Publications, Posters and Presentations:

This project was supported by the Specialized Program of Research Excellence (SPORE) program, through the NIH National Institute for Dental and Craniofacial Research (NIDCR) and National Cancer Institute (NCI), grant P50CA278595. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.